Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles-Reference-Cited by-同舟云学术

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

Published:2022 Issue:3 Volume:10 Page:794-807
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Pan Zhicheng¹^ORCID,Yang Guangxuan¹,Yuan Jinfeng¹,Pan Mingwang¹^ORCID,Li Jiehua²,Tan Hong²^ORCID

Affiliation:

1. Hebei Key Laboratory of Functional Polymers, Department of Polymer Materials and Engineering, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China

2. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

Abstract

The higher density of the disulfide bond and longer mPEG chain can accelerate the micellar degradation process due to the disproportionate hydrophobic/hydrophilic ratio of the broken polymer chain.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01422F

Reference47 articles.

1. Smart chemistry in polymeric nanomedicine

2. Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval