Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy-Reference-Cited by-同舟云学术

Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy

Published:2023 Issue:2 Volume:14 Page:1024-1036
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Weili¹,Li Haiyang¹,Zheng Lujuan¹,Xia Jing¹,Yang Xiaoxuan¹,Men Shuhan¹,Yuan Ye¹,Fan Yuying¹^ORCID

Affiliation:

1. Engineering Research Center of Glycoconjugates of Ministry of Education, Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun, China

Abstract

Ginsenoside CK relies on the DRP1/PINK1 pathway to activate mitophagy for removing damaged mitochondria, therefore ameliorating mitochondrial quality and dysfunction and relieving skeletal muscle insulin resistance in diabetic mice.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO02026B

Reference44 articles.

1. Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

2. Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

3. Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications