Development of an α′-hydroxy enone for the aminocatalytic asymmetric formal conjugate addition of aldehydes to acrylates, vinyl ketones and acrolein

Abstract

Formally, a unified enantioselective conjugate addition of aldehydes to acrolein, alkyl–vinyl ketones and acrylic esters is feasible using simple commercially available aminocatalysts and α′-hydroxy enones as self-activated acceptor templates.