Unlocking mild-condition benzene ring contraction using nonheme diiron N-oxygenase

Author:

Guo Yuan-Yang1ORCID,Tian Ze-Hua1,Ma ChunHua1ORCID,Han Yu-Chen1,Bai DaChang1,Jiang ZhiYong1

Affiliation:

1. State Key Laboratory of Antiviral Drugs, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China

Abstract

Benzene ring contractions are thermodynamically challenging and are typically performed under harsh conditions. This study reports a broad scope, enzymatic, one-step and one-pot reaction for benzene ring contraction under mild conditions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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