Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs-Reference-Cited by-同舟云学术

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

Published:2022 Issue:9 Volume:14 Page:3452-3466
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Radziwon Agata¹^ORCID,Bhangu Sukhvir K.²^ORCID,Fernandes Soraia³^ORCID,Cortez-Jugo Christina¹^ORCID,De Rose Robert¹^ORCID,Dyett Brendan²^ORCID,Wojnilowicz Marcin¹^ORCID,Laznickova Petra³^ORCID,Fric Jan³⁴^ORCID,Forte Giancarlo³^ORCID,Caruso Frank¹^ORCID,Cavalieri Francesca²⁵^ORCID

Affiliation:

1. Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

2. School of Science, RMIT University, Melbourne, Victoria 3000, Australia

3. International Clinical Research Center (ICRC), St Anne's University Hospital, CZ-65691 Brno, Czech Republic

4. Institute of Hematology and Blood Transfusion, Prague, Czech Republic

5. Dipartimento di Scienze e Tecnologie Chimiche, Università degli Studi di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133, Rome, Italy

Abstract

Nanocomplexes of glycogen nanoparticles with serum albumin were formed by triggering the nanophase separation of albumin. The nanocomplexes enabled the delivery of chemotherapeutics in complex multicellular 3D tumour-like structures.

Funder

Australian Research Council

National Health and Medical Research Council

H2020 Marie Skłodowska-Curie Actions

European Regional Development Fund

Royal Melbourne Institute of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR08429A