Rational design of a dual-reactive probe for imaging the biogenesis of both H<sub>2</sub>S and GSH from <scp>l</scp>-Cys rather than <scp>d</scp>-Cys in live cells-Reference-Cited by-同舟云学术

Rational design of a dual-reactive probe for imaging the biogenesis of both H₂S and GSH from l-Cys rather than d-Cys in live cells

Published:2022 Issue:7 Volume:3 Page:848-852
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Ye Haishun¹,Cheng Longhuai²^ORCID,Tu Xiaoqiang¹,Wang Da-Wei²,Yi Long¹^ORCID

Affiliation:

1. State Key Laboratory of Organic-Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology (BUCT), Beijing 100029, China

2. State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, National Pesticide Engineering Research Center, Nankai University, Tianjin, 300071, China

Abstract

Using both thiolysis of NBD amine and CBD arylether as dual receptors, we rationally design a dual-quenching probe for the detection of the biogenesis of H2S + GSH derived from l-Cys rather than d-Cys in live cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00105E

Reference81 articles.

1. H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

2. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

3. Chemical Biology of H2S Signaling through Persulfidation

4. One- and two-electron oxidation of thiols: mechanisms, kinetics and biological fates

5. Widespread occurrence of covalent lysine–cysteine redox switches in proteins

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