Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers-Reference-Cited by-同舟云学术

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

Published:2017 Issue:9 Volume:15 Page:2086-2096
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zanato Chiara¹²³⁴⁵,Pelagalli Alessia¹²³⁴⁵,Marwick Katie F. M.⁶⁷⁸⁵,Piras Monica¹²³⁴⁵,Dall'Angelo Sergio¹²³⁴⁵,Spinaci Andrea¹²³⁴⁵^ORCID,Pertwee Roger G.¹²³⁴⁵^ORCID,Wyllie David J. A.⁶⁷⁸⁵,Hardingham Giles E.⁶⁷⁸⁵,Zanda Matteo¹²³⁴⁵^ORCID

Affiliation:

1. Kosterlitz Centre for Therapeutics

2. Institute of Medical Sciences

3. University of Aberdeen

4. Aberdeen

5. UK

6. Centre for Integrative Physiology

7. University of Edinburgh

8. Edinburgh

Abstract

Prospective PET tracers HU-210F and HU-211F were synthesised and tested as ligands of cannabinoid (CB₁ and CB₂) and N-methyl d-aspartate (NMDAR) receptors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02796B

Reference29 articles.

1. In vivoimaging of the cannabinoid CB1receptor with positron emission tomography

2. 4-Cyano-5-(2-thiophenyl)-pyrazoles are high affinity CB1 receptor ligands

3. Development of Radioligands for In Vivo Imaging of Type 1 Cannabinoid Receptors (CB1) in Human Brain

4. Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135

5. Enantiomeric cannabinoids: stereospecificity of psychotropic activity

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