Nitro-enabled catalytic enantioselective formal umpolung alkenylation of β-ketoesters
Author:
Affiliation:
1. Department of Organic Chemistry
2. Indian Institute of Science
3. Bangalore 560 012
4. India
Abstract
A formal umpolung strategy is presented for the enantioselective installation of an alkenyl group with a terminal double bond at a tertiary center. This one-pot two-step sequence relies on the unique features of the nitro group, which after inverting the polarity of the alkenylating agent toward the desired bond formation, itself serves as a leaving group.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC02232H
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