Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity
Author:
Affiliation:
1. Department of Biochemistry
2. UT Southwestern Medical Center
3. Dallas
4. USA
5. Department of Pediatrics
Abstract
Spiroindimicins A and H have been synthesized for the first time via a key palladium-catalyzed spirocyclization. Access to these alkaloids and several congeners has allowed the discovery of their antiparasitic properties.
Funder
University of Texas Southwestern Medical Center
Welch Foundation
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02838C
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