Immunogenic dead cells engineered by the sequential treatment of ultraviolet irradiation/cryo-shocking for lung-targeting delivery and tumor vaccination

Author:

Zang Jing1ORCID,Zhang Jinniu1,Mei Yijun2ORCID,Xiong Yaoxuan1,Ci Tianyuan1ORCID,Feng Nianping1ORCID

Affiliation:

1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

2. School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu province, 210009, China

Abstract

Immunogenic dead cells are engineered by sequential tumor treatment with ultraviolet irradiation and cryo-shocking. The drug-loaded dead cells can serve as a lung-targeting vehicle and tumor vaccine to mediate the chemoimmunotherapy of lung cancer.

Funder

National Natural Science Foundation of China

Shanghai Rising-Star Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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