A novel HPLC method for the determination of zonisamide in human plasma using microextraction by packed sorbent optimised by experimental design-Reference-Cited by-同舟云学术

A novel HPLC method for the determination of zonisamide in human plasma using microextraction by packed sorbent optimised by experimental design

Published:2017 Issue:40 Volume:9 Page:5910-5919
ISSN:1759-9660
Container-title:Anal. Methods
language:en
Short-container-title:Anal. Methods

Author:

Lourenço Dina¹²³⁴⁵,Sarraguça Mafalda⁶⁷⁸⁹¹⁰^ORCID,Alves Gilberto¹¹¹²¹³¹⁴¹⁵,Coutinho Paula¹²³⁴⁵^ORCID,Araujo André R. T. S.¹²³⁴⁵^ORCID,Rodrigues Márcio¹²³⁴⁵^ORCID

Affiliation:

1. CPIRN-UDI/IPG

2. Centro de Potencial e Inovação em Recursos Naturais

3. Unidade de Investigação para o Desenvolvimento do Interior

4. Instituto Politécnico da Guarda

5. 6300-559 Guarda

6. LAQV/REQUIMTE

7. Departamento de Ciências Químicas

8. Faculdade de Farmácia

9. Universidade do Porto

10. 4050-313 Porto

11. CICS-UBI

12. Centro de Investigação em Ciências da Saúde

13. Universidade da Beira Interior

14. 6200-506 Covilhã

15. Portugal

Abstract

A novel high-performance liquid chromatography-diode array detection method based on microextraction by packed sorbent as a sample preparation approach was developed and validated for the determination of zonisamide in human plasma.

Funder

Portuguese Science and Technology Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/AY/C7AY01912B

Reference45 articles.

1. Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults

2. Zonisamide in the treatment of epilepsy

3. Zonisamide in the management of epilepsy in the elderly