Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments-Reference-Cited by-同舟云学术

Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments

Published:2019 Issue:6 Volume:17 Page:1487-1505
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mears Paul R.¹²³⁴,Hoekman Steven¹²³⁴,Rye Claire E.¹²³⁴,Bailey Fiona P.⁵⁶⁷⁸⁴,Byrne Dominic P.⁵⁶⁷⁸⁴,Eyers Patrick A.⁵⁶⁷⁸⁴^ORCID,Thomas Eric J.¹²³⁴^ORCID

Affiliation:

1. The School of Chemistry

2. The University of Manchester

3. Manchester

4. UK

5. The Department of Biochemistry

6. IIB

7. The University of Liverpool

8. Liverpool

Abstract

The syntheses of compounds corresponding to 20,20-difluorinated C17–C27 fragments of bryostatin are reported together with preliminary PKC binding data.

Funder

Engineering and Physical Sciences Research Council

North West Cancer Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB03152E

Reference83 articles.

1. Bryozoan metabolites: an ecological perspective

2. P. A. Wender , Products in Medicinal Chemistry , ed. S. Hanessian , Wiley-VCH Verlag GmbH & Co., KGaA , Weinheim, Germany , 2014 , p. 475