Can we predict the intracellular metabolic state of a cell based on extracellular metabolite data?-Reference-Cited by-同舟云学术

Can we predict the intracellular metabolic state of a cell based on extracellular metabolite data?

Published:2015 Issue:12 Volume:11 Page:3297-3304
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Granucci Ninna¹²³⁴,Pinu Farhana R.¹²³⁴⁵,Han Ting-Li¹²³⁴,Villas-Boas Silas G.¹²³⁴

Affiliation:

1. School of Biological Sciences

2. University of Auckland

3. Private Bag 92019

4. New Zealand

5. The New Zealand Institute for Plant and Food Research Limited

Abstract

Based on the metabolic overflow concept, a given metabolite is secreted to the extracellular medium when its intracellular levels increase. But this phenomenon can only be truly observed experimentally by using dynamic metabolite level measurements of both intra and extracellular media under time series experiments.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00292C

Reference31 articles.

1. Production of plant sesquiterpenes inSaccharomyces cerevisiae: Effect ofERG9 repression on sesquiterpene biosynthesis

2. Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

3. Overproduction of fatty acids in engineeredSaccharomyces cerevisiae