Amorphous poly-<i>N</i>-vinylcarbazole polymer as a novel matrix for the determination of low molecular weight compounds by MALDI-TOF MS-Reference-Cited by-同舟云学术

Amorphous poly-N-vinylcarbazole polymer as a novel matrix for the determination of low molecular weight compounds by MALDI-TOF MS

Published:2022 Issue:24 Volume:12 Page:15215-15221
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chen Xiu-Ying¹²³,Wang Yong-hui²,Ren Shu-Yue²,Li Shuang²^ORCID,Wang Yu²^ORCID,Qin Kang²,Li Sen²,Han Dian-Peng²,Peng Yuan²,Han Tie²,Gao Zhi-Xian²,Gao Bao-Xiang¹^ORCID,Zhou Huan-ying²^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, College of Chemical and Environmental Sciences, Hebei University, Baoding 071002, China

2. Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China

3. Nanpu Development Zone Administrative Examination and Approval Bureau, Tangshan 063305, China

Abstract

Amorphous, highly salt tolerant and stable polymer PVK as a negative ion mode matrix was successfully achieved for the qualitative and quantitative detection of small molecule compounds by MALDI MS.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA01602H

Reference43 articles.

1. Laser Desorption/Ionization Mass Spectrometry of Proteins of Mass 100 000 to 250 000 Dalton

2. Detection of 25,000 molecules of Substance P by MALDI-TOF mass spectrometry and investigations into the fundamental limits of detection in MALDI

3. MALDI Mass Spectrometry for Direct Tissue Analysis: A New Tool for Biomarker Discovery