Self-fluorescent antibiotic MoOx–hydroxyapatite: a nano-theranostic platform for bone infection therapies

Author:

Placente Damián12345,Ruso Juan. M.678910ORCID,Baldini Mónica1112345,Laiuppa Juan A.1112345,Sieben Juan M.13143155,Santillán Graciela E.1112345ORCID,Messina Paula V.12345ORCID

Affiliation:

1. INQUISUR – CONICET

2. Department of Chemistry

3. Universidad Nacional del Sur

4. Bahía Blanca

5. Argentina

6. Soft Matter and Molecular Biophysics Group

7. Department of Applied Physics

8. University of Santiago de Compostela

9. 15782 Santiago de Compostela

10. Spain

11. Department of Biology

12. Biochemistry and Pharmacy

13. INIEC – CONICET

14. Department of Chemistry Engineering

15. B8000CPB Bahía Blanca

Abstract

Unusual intrinsic electronic point defects of bone-mimetic hydroxyapatite nanoparticles induce a self-activated fluorescence and provoke pathogen microorganisms’ death after their direct contact.

Funder

Secretaría General de Ciencia y Tecnología, Universidad Nacional del Sur

Consejo Nacional de Investigaciones Científicas y Técnicas

Xunta de Galicia

Fondo para la Investigación Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference55 articles.

1. National Institutes of Health , Understanding emerging and re-emerging infectious diseases , Biological sciences curriculum study. NIH Curriculum Supplement Series. National Institutes of Health , Bethesda, MD , 2007

2. Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions

3. 3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection

4. Nanoparticulate drug delivery platforms for advancing bone infection therapies

5. J. S. Gogia , J. P.Meehan , P. E.Di Cesare and A. A.Jamali , Local Antibiotic Therapy in Osteomyelitis , 2009

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