Discovery and characterization of a novel peptide inhibitor against influenza neuraminidase-Reference-Cited by-同舟云学术

Discovery and characterization of a novel peptide inhibitor against influenza neuraminidase

Published:2020 Issue:1 Volume:11 Page:148-154
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Chen Jianmei¹²³⁴⁵,Feng Shujun¹²³⁴⁵,Xu Yurui¹²³⁴⁵,Huang Xinyu¹²³⁴⁵,Zhang Jikang¹²³⁴⁵,Chen Jiao⁶⁵⁷,An Xueying⁸⁹¹⁰¹¹¹²,Zhang Yu¹²³⁴⁵,Ning Xinghai¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Nanjing National Laboratory of Microstructures

3. College of Engineering and Applied Sciences

4. Nanjing University

5. Nanjing

6. Jiangsu Province Academy of Traditional Chinese Medicine

7. China

8. State Key Laboratory of Pharmaceutical Biotechnology

9. Department of Sports Medicine and Adult Reconstructive Surgery

10. Nanjing Drum Tower Hospital

11. The Affiliated Hospital of Nanjing University Medical School

12. Nanjing 210008

Abstract

An optimized octapeptide (errKPAQP), exhibits nanomolar affinity to influenza neuraminidase, can notably inhibit neuraminidase activity, and protect mice from influenza infection in vivo, indicating that errKPAQP is a promising anti-influenza drug.

Funder

National Natural Science Foundation of China

Nanjing University

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00473D

Reference36 articles.

1. Surveillance of Animal Influenza for Pandemic Preparedness