In silico strategy for isoform-selective 5-HT2AR and 5-HT2CR inhibitors

Author:

Geng Xiaohui1234ORCID,Wang Ying5234ORCID,Wang Huibin1234ORCID,Hu Baichun62347,Huang Junhao1234ORCID,Wu Yiheng62347ORCID,Wang Jian62347ORCID,Zhang Fengjiao5234ORCID

Affiliation:

1. School of Pharmacy

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. People's Republic of China

5. Wuya College of Innovation

6. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education

7. School of Pharmaceutical Engineering

Abstract

5-HT2AR and 5-HT2CR are widely expressed throughout the brain and have been drawing significant clinical interest due to their involvement in mediating mental disorders.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Reference29 articles.

1. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

2. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2b) receptor gene products: comparison with 5-HT2a and 5-HT2c receptors

3. T. Watanabe and S.Koba , Roles of Serotonin in Atherothrombosis and Related Diseases, Traditional and novel risk factors in atherothrombosis , InTech. , 2012

4. I. Raote , A.Bhattacharya and M. M.Panicker , in Serotonin Receptors in Neurobiology , ed. A. Chattopadhyay , Boca Raton (FL) , 2007

5. Serotonin 5-HT2A and 5-HT2C Receptors as Potential Targets for Modulation of Psychostimulant Use and Dependence

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