Abstract
Because the overwhelming majority of biological drugs are protein/peptide drugs, the main focus of this chapter is placed on the mechanisms of protein/peptide degradation, such as peptide bond hydrolysis, deamidation, side chain oxidation, disulfide bridge decomposition, β-elimination, and crosslinking, and so on. A few representative degradation mechanisms for carbohydrate- and nucleic acid-based biological drugs are also discussed.
Publisher
The Royal Society of Chemistry