Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage-Reference-Cited by-同舟云学术

Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage

Published:2023 Issue:5 Volume:2 Page:1577-1588
ISSN:2635-098X
Container-title:Digital Discovery
language:en
Short-container-title:Digital Discovery

Author:

Handa Koichi¹^ORCID,Sugiyama Sakae²,Kageyama Michiharu¹,Iijima Takeshi¹

Affiliation:

1. Toxicology & DMPK Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino-shi, Tokyo 191-8512, Japan

2. Medicinal Chemistry Research Laboratories, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino-shi, Tokyo 191-8512, Japan

Abstract

To precisely predict the intestinal absorption ratio (Fa) at an early stage in the discovery, we combined a data-driven (using chemical structures) and mechanism-based approach (using gastrointestinal unified theoretical framework).

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DD/D3DD00144J

Reference55 articles.

1. Advances in Oral Drug Delivery

2. Improving the odds of drug development success through human genomics: modelling study

3. Firm involved in drug trial fiasco files for bankruptcy

4. Equivalence Studies of Pravastatin Original and Generic Drugs by Dissolution Test

5. Parallel Artificial Membrane Permeability Assay: A New Membrane for the Fast Prediction of Passive Human Skin Permeability

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