Recent syntheses and biological profiling of quassinoids

Author:

Pazur Ethan J.1,Wipf Peter12ORCID

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA

2. School of Pharmacy, University of Eastern Finland, FI-70210 Kuopio, Finland

Abstract

Quassinoids exhibit diverse biological properties and pose synthetically challenging targets. Focusing on accomplishments over the past 15 years, we discuss strategies and tactics of total syntheses as well as SAR and biological functions.

Funder

Academy of Finland

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference58 articles.

1. J.Polonsky , Quassinoid Bitter Principles II , in Progress in the Chemistry of Organic Natural Products , ed. W. Herz , H. Grisebach , G. W. Kirby and C. Tamm , Springer , Vienna , 1st edn, 1985 , pp. 221–264

2. J.Polonsky , Chemistry and Biogenesis of the Quassinoids (Simaroubolides) , in Recent Advances of Phytochemistry , ed. V. C. Runeckles and T. J. Mabry , Academic Press , New York , 1973 , vol. 6 , pp. 31–64

3. Unprecedented Quassinoids from Eurycoma longifolia: Biogenetic Evidence and Antifeedant Effects

4. Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico

5. Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities

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