Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents

Published:2023 Issue:2 Volume:14 Page:313-331
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gonçalves Bruno M. F.¹²,Mendes Vanessa I. S.¹²,Silvestre Samuel M.²³^ORCID,Salvador Jorge A. R.²⁴^ORCID

Affiliation:

1. CHEM4PHARMA, Biocant – Parque Tecnológico de Cantanhede, Núcleo 4, Lote 14, 3060-197, Cantanhede, Portugal

2. Center for Neuroscience and Cell Biology, Coimbra, Portugal

3. CICS-UBI – Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal

4. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal

Abstract

Arjunolic acid derivatives containing a pentameric A-ring were prepared. The biological activity on the viability of human cancer and non-tumor cell lines was evaluated as well as the molecular mechanism of action in PANC-1 cells for compound 26.

Funder

Programa Operacional Regional do Centro

Universidade de Coimbra

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00275B

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