Synthesis, biological activities, and evaluation molecular docking-dynamics studies of new phenylisoxazole quinoxalin-2-amine hybrids as potential α-amylase and α-glucosidase inhibitors-Reference-Cited by-同舟云学术

Synthesis, biological activities, and evaluation molecular docking-dynamics studies of new phenylisoxazole quinoxalin-2-amine hybrids as potential α-amylase and α-glucosidase inhibitors

Published:2024 Issue:11 Volume:14 Page:7684-7698
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mohd Radzuan Siti Nurshahira¹^ORCID,Phongphane Lacksany¹,Abu Bakar Mohamad Hafizi²,Che Omar Mohammad Tasyriq³,Nor Shahril Nor Shafiqah²,Supratman Unang⁴^ORCID,Harneti Desi⁴,Wahab Habibah A.⁵,Azmi Mohamad Nurul¹^ORCID

Affiliation:

1. School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

2. Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

3. Biological Section, School of Distance Education, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

4. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, 45363 Jatinangor, Indonesia

5. School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

Abstract

New phenylisoxazole quinoxalin-2-amine hybrids 5a–i were successfully synthesised with yields of 53–85% and characterised with various spectroscopy methods.

Funder

Ministry of Higher Education, Malaysia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08642A

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