Fingering instability in spreading epithelial monolayers: roles of cell polarisation, substrate friction and contractile stresses-Reference-Cited by-同舟云学术

Fingering instability in spreading epithelial monolayers: roles of cell polarisation, substrate friction and contractile stresses

Published:2021 Issue:36 Volume:17 Page:8276-8290
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Trenado Carolina¹^ORCID,Bonilla Luis L.¹^ORCID,Martínez-Calvo Alejandro²³⁴^ORCID

Affiliation:

1. Department of Mathematics, Gregorio Millán Institute, Fluid Dynamics, Nanoscience and Industrial Mathematics, Universidad Carlos III de Madrid, 28911 Leganés, Spain

2. Grupo de Mecánica de Fluidos, Gregorio Millán Institute, Fluid Dynamics, Nanoscience and Industrial Mathematics, Universidad Carlos III de Madrid, 28911 Leganés, Spain

3. Princeton Center for Theoretical Science, Princeton University, Princeton, NJ 08544, USA

4. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA

Abstract

Numerical simulations and linear stability analyses of expanding cellular monolayers suggest cell–substrate friction is responsible for fingers at the edge. A critical contractile stress characterises wetting-dewetting; dewetting inhibits fingering.

Funder

Human Frontier Science Program

Comunidad de Madrid

Ministerio de Ciencia, Innovación y Universidades

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SM/D1SM00626F

Reference81 articles.

1. Channeling in packed columns