Direct inhibition of the first PDZ domain of ZO-1 by glycyrrhizin is a possible mechanism of tight junction opening of Caco-2 cells-Reference-Cited by-同舟云学术

Direct inhibition of the first PDZ domain of ZO-1 by glycyrrhizin is a possible mechanism of tight junction opening of Caco-2 cells

Published:2022 Issue:4 Volume:13 Page:1953-1964
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Hibino Emi¹,Goda Natsuko¹,Hisada Misaki¹,Tenno Takeshi¹²,Hiroaki Hidekazu¹²^ORCID

Affiliation:

1. Laboratory of Structural Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan

2. BeCellBar LLC., Business Incubation Building, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan

Abstract

Glycyrrhizin (GL) is known to prolong tight junction opening when co-administrated with sodium deoxycholate. Our NMR study revealed the direct binding of GL to the first domain of ZO-1 is one of the mechanisms.

Funder

Japan Science and Technology Agency

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO03062K

Reference39 articles.

1. Review of Pharmacological Effects ofGlycyrrhiza sp. and its Bioactive Compounds

2. A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice

3. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

4. Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte–endothelial interactions

5. Glycyrrhizin Binds to High-Mobility Group Box 1 Protein and Inhibits Its Cytokine Activities

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanism of Intestinal Epithelial Absorption and Electrophysiological Regulation of the Shrimp Peptide QMDDQ;Journal of Agricultural and Food Chemistry;2023-12-29

2. Pharmacologic Comparison of High-Dose Hesperetin and Quercetin on MDCK II Cell Viability, Tight Junction Integrity, and Cell Shape;Antioxidants;2023-04-18