Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups-Reference-Cited by-同舟云学术

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups

Published:2020 Issue:1 Volume:11 Page:169-179
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tu Julian¹²³⁴⁵^ORCID,Svatunek Dennis⁶⁷⁸⁵^ORCID,Parvez Saba⁹²³⁴⁵^ORCID,Eckvahl Hannah J.⁶⁷⁸⁵^ORCID,Xu Minghao¹²³⁴⁵^ORCID,Peterson Randall T.⁹²³⁴⁵,Houk K. N.⁶⁷⁸⁵^ORCID,Franzini Raphael M.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. College of Pharmacy

3. University of Utah

4. Salt Lake City

5. USA

6. Department of Chemistry and Biochemistry

7. University of California

8. Los Angeles

9. Department of Pharmacology and Toxicology

Abstract

Tetrazylmethyl groups are reported here as bioorthogonal protecting groups that are readily removed by isonitriles, establishing a valuable addition to the dissociative bioorthogonal chemistry and synthetic methodology toolboxes.

Funder

National Institutes of Health

American Cancer Society

Austrian Science Fund

University of Utah

Huntsman Cancer Institute

Utah Science Technology and Research

American Foundation for Pharmaceutical Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry