Selection of DNA aptamers for sensing drugs treating eye disease: atropine and timolol maleate

Author:

Wong Ka-Ying12,Liu Yibo12,Phan Chau-Minh23,Jones Lyndon23,Wong Man-Sau245,Liu Juewen12ORCID

Affiliation:

1. Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada

2. Centre for Eye and Vision Research (CEVR), 17W Science Park, Hong Kong, Hong Kong

3. Centre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Canada

4. Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

5. Research Center for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PR China

Abstract

Using capture-SELEX, DNA aptamers for two important ocular drugs were obtained, allowing highly sensitive detection of low volume samples.

Publisher

Royal Society of Chemistry (RSC)

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