Gold nanoparticle-streptavidin conjugates for rapid and efficient screening of aptamer function in lateral flow sensors using novel CD4-binding aptamers identified through Crossover-SELEX

Abstract

Adaptation of conventional lateral flow tests: demonstration of a lateral flow assay in which gold nanoparticle conjugates, when bound to aptamers, serve as a reporting system to screen novel aptamers for the ability to bind to target proteins.