Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives-Reference-Cited by-同舟云学术

Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives

Published:2015 Issue:23 Volume:5 Page:17444-17450
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Huang Chao¹²³⁴⁵,Yan Sheng-Jiao¹²³⁴⁵,Zeng Xiang-Hui¹²³⁴⁵,Sun Bo⁶⁷⁸⁹,Lan Min-Bo⁶⁷⁸⁹,Lin Jun¹²³⁴⁵

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)

2. Ministry Education

3. School of Chemical Science and Technology

4. Yunnan University

5. Kunming

6. Shanghai Key Laboratory of Functional Materials Chemistry and Research Centre of Analysis and Test

7. East China University of Science and Technology

8. Shanghai 200237

9. P. R. China

Abstract

A series of polyhalo acridone heterocyclic compounds were synthesized and evaluated for theirin vitroantitumor activity. Compounds4d,4o,5jand5kshowed good antineoplastic selectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA12354A

Reference38 articles.

1. The Effect of Polyamine Homologation on the Transport and Cytotoxicity Properties of Polyamine−(DNA-Intercalator) Conjugates

2. Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

3. The antiviral agent 5-chloro-1,3-dihydroxyacridone interferes with assembly and maturation of herpes simplex virus

4. New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection

5. Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor

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