Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-Reference-Cited by-同舟云学术

Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Published:2016 Issue:1 Volume:5 Page:312-317
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

David Rhiannon M.¹²³⁴,Gooderham Nigel J.¹²³⁴

Affiliation:

1. Computational and Systems Medicine

2. Department of Surgery and Cancer

3. Imperial College

4. UK

Abstract

The micronucleus (MN) assay can be successfully applied to spheroids of MCF-7 cells to detect DNA damage.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00343A

Reference28 articles.

1. Dietary Benzo[a]Pyrene Intake and Risk of Colorectal Adenoma

2. Benzo( a )pyrene and Other Polynuclear Hydrocarbons in Charcoal-Broiled Meat

3. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 92, Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures, 2010

4. Human exposure to heterocyclic amine food mutagens/carcinogens: Relevance to breast cancer

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