Ring expansion of spirocyclopropanes with stabilized sulfonium ylides: highly diastereoselective synthesis of cyclobutanes-Reference-Cited by-同舟云学术

Ring expansion of spirocyclopropanes with stabilized sulfonium ylides: highly diastereoselective synthesis of cyclobutanes

Published:2024 Issue:34 Volume:60 Page:4537-4540
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Nambu Hisanori¹²^ORCID,Onuki Yuta¹,Aso Kana¹,Kanamori Momoka¹,Tomohara Keisuke²,Tsuge Kiyoshi³,Yakura Takayuki¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan

2. Laboratory of Pharmaceutical Manufacturing Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan

3. Graduate School of Science and Engineering, University of Toyama, Gofuku, Toyama 930-8555, Japan

Abstract

A novel method was devised for regioselective ring expansion of spirocyclopropanes to spirocyclobutanes with stabilized sulfonium ylides, affording 1,2-trans-disubstituted 6,8-dioxaspiro[3.5]nonane-5,9-diones without the formation of any isomers.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Hoansha Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC06033K

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