A general catalytic synthetic strategy for highly strained methylenecyclobutanes and spiromethylenecyclobutanes

Author:

Zhao Haotian1,Lin Yu1,Jiang Mingyu1,Su Bo1ORCID

Affiliation:

1. State Key Laboratory of Medical Chemical Biology, College of Pharmacy, Nankai University, 38 Tongyan Road, Jinnan District, Tianjin, 300350, P. R. China

Abstract

We developed a copper-catalyzed stereoselective strategy for the unified synthesis of borylated methylenecyclobutanes. The versatile boromethylene unit greatly expands their structural diversity and potential in future drug discovery.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Nankai University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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