Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: efficient construction of 2-azaspiro[4.5]decanes-Reference-Cited by-同舟云学术

Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: efficient construction of 2-azaspiro[4.5]decanes

Published:2016 Issue:18 Volume:52 Page:3709-3712
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hu Bei¹²³⁴,Li Yuyuan⁵⁶⁷⁴,Dong Wuheng¹²³⁴,Ren Kai¹²³⁴,Xie Xiaomin¹²³⁴,Wan Jun⁵⁶⁷⁴,Zhang Zhaoguo¹²³⁴⁸

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Shanghai Jiao Tong University

3. Shanghai 200240

4. China

5. College of Chemistry and Molecular Engineering and College of Environment and Safety Engineering

6. Qingdao University of Science and Technology

7. Qingdao 266042

8. Shanghai Institute of Organic Chemistry

Abstract

An efficient intramolecular dearomative cyclization via visible light-induced photoredox catalysis allows for a highly regioselective dearomative cyclization of α-bromo-N-benzyl-alkylamides to construct 2-azaspiro[4.5]decanes in the presence of an iridium catalyst.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC09726F

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4. π-Face selective azaspirocyclization of ω-(methoxyphenyl)-N-methoxyalkylamides

5. Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease

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