E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
Author:
Affiliation:
1. CONTINUUS Pharmaceuticals
2. Woburn
3. USA
4. IMA S.p.a.
5. Bologna
6. Food and Drug Administration
7. Silver Spring
8. USV Private Limited
9. Mumbai
10. India
Abstract
Much less waste was generated by the end-to-end Integrated Continuous Manufacturing (ICM) process compared to the batch process.
Funder
U.S. Food and Drug Administration
Publisher
Royal Society of Chemistry (RSC)
Subject
Pollution,Environmental Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/GC/D0GC01397H
Reference42 articles.
1. End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts
2. The future of pharmaceutical quality and the path to get there
3. Monitoring of the combined cooling and antisolvent crystallisation of mixtures of aminobenzoic acid isomers using ATR-UV/vis spectroscopy and FBRM
4. Comparative Investigation of Supersaturation and Automated Direct Nucleation Control of Crystal Size Distributions using ATR-UV/vis Spectroscopy and FBRM
5. In Situ Monitoring of Polymorphic Transformations Using a Composite Sensor Array of Raman, NIR, and ATR-UV/vis Spectroscopy, FBRM, and PVM for an Intelligent Decision Support System
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