Stereospecific synthetic approach towards Tamiflu using the Ramberg–Backlund reaction from cysteine hydrochloride-Reference-Cited by-同舟云学术

Stereospecific synthetic approach towards Tamiflu using the Ramberg–Backlund reaction from cysteine hydrochloride

Published:2014 Issue:107 Volume:4 Page:62281-62284
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Chavan Subhash P.¹²,Chavan Prakash N.¹²,Gonnade Rajesh G.³²

Affiliation:

1. Organic Chemistry Division

2. Pune-411008, India

3. Center for Material Characterization CSIR – National Chemical Laboratory

Abstract

The stereospecific formal synthesis of Tamiflu from l-cysteine hydrochloride as the chiral source is described. The notable feature of the present strategy is the Ramberg–Backlund reaction and Sharpless–Reich protocol as the key chemical transformations to access the cyclohexene skeleton of Tamiflu.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA10391B

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