A photo-activated aptamer–drug conjugate for targeted drug delivery-Reference-Cited by-同舟云学术

A photo-activated aptamer–drug conjugate for targeted drug delivery

Published:2022 Issue:77 Volume:58 Page:10797-10800
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Jing¹²,Liu Xiangjun¹²^ORCID,Yi Mengwen¹,Sun Yue¹,Bing Tao¹²^ORCID,Zhang Nan¹,Shangguan Dihua¹²³^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

2. University of Chinese Academy of Sciences, Beijing, 100049, China

3. School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China

Abstract

A photo-activated ApDC, HG1-9–DNP, could be internalized into target cells mediated by TfR, then photocleaved and released a promising cytotoxic agent DNNH, which arrested the cell cycle at the G2/M phase, resulting in high cytotoxicity.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC04045J

Reference28 articles.

1. Designing materials for biology and medicine

2. Challenges in design and characterization of ligand-targeted drug delivery systems

3. A targeted drug delivery system based on folic acid-functionalized upconversion luminescent nanoparticles

4. Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

5. Preparation and characterization of a dual-receptor mesoporous silica nanoparticle–hyaluronic acid–RGD peptide targeting drug delivery system

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