Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S-Reference-Cited by-同舟云学术

Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S

Published:2023 Issue:9 Volume:4 Page:692-697
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Müll Maximilian¹,Pourmasoumi Farzaneh¹,Wehrhan Leon²,Nosovska Olena³,Stephan Philipp¹,Zeihe Hannah¹,Vilotijevic Ivan³^ORCID,Keller Bettina G.²^ORCID,Kries Hajo¹⁴^ORCID

Affiliation:

1. Junior Research Group Biosynthetic Design of Natural Products, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI Jena), Jena 07745, Germany

2. Freie Universität Berlin, Department of Biology, Chemistry, and Pharmacy, Institute of Chemistry and Biochemistry, Arnimallee 20, Berlin 14195, Germany

3. Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany

4. University of Bayreuth, Organic Chemistry I, Bayreuth 95440, Germany

Abstract

Since fluorinated compounds are vital in medicinal chemistry, incorporating fluorine into natural products is attracting interest. We enable incorporation of 4-fluoro-Phe into the nonribosomal peptide gramicidin S with a surgical mutation.

Funder

International Leibniz Research School for Microbial and Biomolecular Interactions

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Jena School for Microbial Communication, Friedrich-Schiller-Universität Jena

Bundesministerium für Bildung und Forschung

Max-Buchner-Forschungsstiftung

Daimler und Benz Stiftung

Fonds der Chemischen Industrie

Publisher

Royal Society of Chemistry (RSC)

Subject