High-resolution NMR Studies of Antibiotics in Membranes

Abstract

The rapid rise of antimicrobial resistance calls for the development of new antibiotics. Ideal templates for next-generation antibiotics could be drugs that target the cell wall precursor, Lipid II, with vancomycin, nisin, or teixobactin being well-known examples. In this chapter the authors review a selection of NMR studies on the mode of action of Lipid II-binding antibiotics with an emphasis on solid-state NMR findings in lipid membranes that are vital to obtain physiologically relevant drug-binding modes.