Encapsulation of a nitric oxide donor into a liposome to boost the enhanced permeation and retention (EPR) effect-Reference-Cited by-同舟云学术

Encapsulation of a nitric oxide donor into a liposome to boost the enhanced permeation and retention (EPR) effect

Published:2017 Issue:2 Volume:8 Page:415-421
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Tahara Yu¹²³⁴,Yoshikawa Takuma⁵⁶²³⁴,Sato Hikari¹²³⁴,Mori Yukina¹²³⁴,Zahangir Md Hosain¹²³⁴,Kishimura Akihiro¹²³⁴⁵^ORCID,Mori Takeshi¹²³⁴⁵^ORCID,Katayama Yoshiki¹²³⁴⁵

Affiliation:

1. Graduate School of Systems Life Sciences

2. Kyushu University

3. Fukuoka 819-0395

4. Japan

5. Department of Applied Chemistry

6. Faculty of Engineering

Abstract

We propose a method to improve the enhanced permeability and retention (EPR) effect of nanomedicines based on tumor-specific vasodilation using a nitric oxide (NO) donor-containing PEGylated liposome.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00614K

Reference40 articles.

1. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

2. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

3. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

4. Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

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