An improved enzymatic method for the preparation of (R)-phenylacetyl carbinol-Reference-Cited by-同舟云学术

An improved enzymatic method for the preparation of (R)-phenylacetyl carbinol

Published:2017 Issue:52 Volume:7 Page:32664-32668
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Heng¹²³⁴⁵^ORCID,Liu Nan⁶⁷⁸⁴⁵,Hui Xian¹²³⁴⁵,Gao Wen-Yun¹²³⁴⁵

Affiliation:

1. National Engineering Research Center for Miniaturized Detection Systems

2. College of Life Sciences

3. Northwest University

4. Xi'an

5. China

6. Department of Experimental Surgery

7. Tangdu Hospital

8. Fourth Military Medical University

Abstract

(R)-Phenylacetyl carbinol (R-PAC) is one of the key chiral α-hydroxyketones utilized as a synthon in the synthesis of a number of pharmaceuticals having α- and β-adrenergic properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA04641C

Reference24 articles.

1. Application of α-keto acid decarboxylases in biotransformations

2. O. P. Ward and A.Singh, Enzyme biotransformation involving α-ketoacid decarboxylases, in Microorganisms for Industrial Enzymes and Biocontrol, ed. E. Mellado and J. L. Barredo, Research Signpost, Thiruvananthapuram, Kerala, 2005, pp. 83–94

3. Aromatic aldehydes as substrates for yeast and yeast alcohol dehydrogenase

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