Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents-Reference-Cited by-同舟云学术

Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents

Published:2020 Issue:21 Volume:10 Page:12272-12288
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Srinivasarao Singireddi¹²³⁴,Nandikolla Adinarayana¹²³⁴,Suresh Amaroju¹²³⁴,Calster Kevin Van⁵⁶⁷⁸⁹,De Voogt Linda⁵⁶⁷⁸⁹,Cappoen Davie⁵⁶⁷⁸⁹,Ghosh Balaram¹⁰²³⁴,Aggarwal Himanshu¹²³⁴,Murugesan Sankaranarayanan¹¹¹⁰²⁴,Chandra Sekhar Kondapalli Venkata Gowri¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Birla Institute of Technology and Science, Pilani

3. Hyderabad-500078

4. India

5. Department of Green Chemistry and Technology

6. Faculty of Bioscience Engineering

7. Ghent University

8. Ghent

9. Belgium

10. Department of Pharmacy

11. Medicinal Chemistry Research Laboratory

Abstract

We herein report 27 pyrazinamide analogues as anti-tubercular agents, of which six exhibited excellent activity with IC₅₀ ≤ 2.18 μM and these were less toxic against HEK 293 cells.

Funder

Department of Biotechnology, Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology, India

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01348J

Reference35 articles.

1. https://apps.who.int/iris/bitstream/handle/10665/311389/9789241550529-eng.pdf