PEGylated cationic nanoassemblies based on triblock copolymers to combine siRNA therapeutics with anticancer drugs-Reference-Cited by-同舟云学术

PEGylated cationic nanoassemblies based on triblock copolymers to combine siRNA therapeutics with anticancer drugs

Published:2021 Issue:18 Volume:9 Page:6251-6265
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Conte Claudia¹^ORCID,Dal Poggetto Giovanni²^ORCID,Schiano Di Cola Viola¹^ORCID,Russo Annapina¹,Ungaro Francesca¹^ORCID,Russo Giulia¹,Laurienzo Paola²^ORCID,Quaglia Fabiana¹²^ORCID

Affiliation:

1. Drug Delivery Laboratory, Department of Pharmacy, University of Napoli Federico II, 80131 Napoli, Italy

2. Institute for Polymers, Composites and Biomaterials, CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy

Abstract

PEGylated cationic NPs based on PEG–pDMAEMA–PCL triblock copolymers are able to condense a therapeutic siRNA and simultaneously entrap the anticancer drug DTX, thus exerting in cancer cells high silencing efficacy and a combined anticancer effect.

Funder

Regione Campania

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00909E

Reference45 articles.

1. Therapeutic siRNA: state of the art

2. siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

3. siRNA delivery systems for cancer treatment