Hypervalent iodine(<scp>iii</scp>)-mediated ring-expansive difluorination of alkynylcyclopropanes <i>en route</i> to the synthesis of difluorinated alkylidenecyclobutanes-Reference-Cited by-同舟云学术

Hypervalent iodine(iii)-mediated ring-expansive difluorination of alkynylcyclopropanes en route to the synthesis of difluorinated alkylidenecyclobutanes

Published:2022 Issue:16 Volume:9 Page:4447-4452
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yang Shuang¹,Liu Xiao-Bin¹,Feng Si-Xin¹,Li Yin¹,Tu Fang-Hai¹,Huang Bin²^ORCID,Huang Long-Ling¹,Huang Zhi-Shu¹^ORCID,Wang Honggen¹^ORCID,Li Qingjiang¹³^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China

2. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, P. R. China

3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P. R. China

Abstract

Reported herein is a hypervalent iodine(iii)-mediated ring-expansive difluorination of alkynylcyclopropanes featuring a Wagner–Meerwein-type rearrangement to access a variety of difluorinated alkylidenecyclobutanes.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

Special Project for Research and Development in Key areas of Guangdong Province

Peking University

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00888B