Theoretical study on enzyme synthesis of cephalexin in a parallel-flow microreactor combined with electrically driven ATPS microextraction-Reference-Cited by-同舟云学术

Theoretical study on enzyme synthesis of cephalexin in a parallel-flow microreactor combined with electrically driven ATPS microextraction

Published:2020 Issue:3 Volume:5 Page:570-583
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Mařík Karel¹²³⁴,Tichá Linda¹²³⁴,Vobecká Lucie¹²³⁴,Přibyl Michal¹²³⁴

Affiliation:

1. Department of Chemical Engineering

2. University of Chemistry and Technology, Prague

3. 166 28 Praha 6

4. Czech Republic

Abstract

A mathematical model of a microfluidic device with two aqueous phases for the simultaneous cephalexin production and its separation from a reaction mixture was developed. The model anticipates the continuous cephalexin synthesis and enzyme recyclation.

Funder

Grantová Agentura České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/C9RE00482C

Reference55 articles.

1. Penicillin G acylase from Achromobacter sp. CCM 4824

2. Integrated reactor concepts for the enzymatic kinetic synthesis of cephalexin