<scp>l</scp>-Fucose increases the fucosylation of colorectal cancer cells <i>via</i> promoting the accumulation of serine-Reference-Cited by-同舟云学术

l-Fucose increases the fucosylation of colorectal cancer cells via promoting the accumulation of serine

Published:2023 Issue:9 Volume:14 Page:4314-4326
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yao Ye¹²,Qian Chengjia³,Chang Zepeng⁴^ORCID,Yang Jiayu²,Chen Yinghan²,Wang Hongchao¹²,Zhu Jinlin¹²,Xiao Yue¹²⁵,Li Yahui⁵,Zhao Jianxin¹²⁶,Lu Wenwei¹²⁵⁶^ORCID

Affiliation:

1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China

2. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China

3. Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214122, China

4. School of Biotechnology, Jiangnan University, Wuxi 214122, China

5. National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China

6. (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China

Abstract

This study uncovers a novel role of serine synthesis and PSAT1 in the regulation of fucosylation and provides insights into the potential application of l-fucose in CRC therapy.

Funder

Higher Education Discipline Innovation Project

Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00820G

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1. Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD