Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach-Reference-Cited by-同舟云学术

Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

Published:2017 Issue:36 Volume:53 Page:5013-5016
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Mattelaer H.-P.¹²³⁴⁵,Mattelaer C.-A.¹²³⁴⁵,Papastavrou N.¹²³⁴⁵,Dehaen W.¹⁶⁷⁴⁵,Herdewijn P.¹²³⁴⁵^ORCID

Affiliation:

1. KU Leuven

2. Rega Institute for Medical Science

3. Medicinal Chemistry

4. 3000 Leuven

5. Belgium

6. Department of Chemistry

7. Molecular Design and Synthesis

Abstract

TransferRNA's role in protein translation is the prime example of an Informational Leaving Group (ILG). A simplified model produced oligophenylalanine with a modified uracil as an ILG in the presence of specific oligonucleotides. Our preliminary studies contribute to the importance of hybrid species in bridging the gap between peptides and nucleic acids.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC00831G

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4. The formation of dipeptides from amino acids and the 2′(3′)-glycyl ester of an adenylate

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