Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides-Reference-Cited by-同舟云学术

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

Published:2021 Issue:4 Volume:8 Page:721-726
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Xin-Ming¹²³⁴^ORCID,Xie Ming⁵⁶⁷⁸⁴,Li Jiazhu¹²³⁴^ORCID,Wang Mei-Xiang⁵⁶⁷⁸⁴^ORCID

Affiliation:

1. College of Chemistry and Chemical Engineering

2. Yantai University

3. Yantai 264005

4. China

5. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education)

6. Department of Chemistry

7. Tsinghua University

8. Beijing 100084

Abstract

An exquisite Pybox/Cu(OTf)₂-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Funder

National Natural Science Foundation of China

Yantai University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01147A

Reference58 articles.

1. Alkaloids from Kopsia griffithii

2. Synthetic Developments on the Indolizidine Alkaloid, Harmicine