Structural characterization of a sulfated polysaccharide from <i>Gracilariopsis lemaneiformis</i> and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis-Reference-Cited by-同舟云学术

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Published:2023 Issue:8 Volume:14 Page:3712-3721
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Cai Bingna¹²^ORCID,Luo Lianxiang³,Chen Xiaodan⁴,Zhao Xiangtan¹,He Jiake³,Chen Hua¹²,Wan Peng¹²^ORCID,Chen Deke¹,Pan Jianyu¹²^ORCID

Affiliation:

1. Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, China

2. Innovation Academy of South China Sea Ecology and Environmental Engineering (ISEE), Chinese Academy of Sciences, Guangzhou 510000, China

3. Experimental Animal Center, Guangdong Medicial University, Zhanjiang 524023, Guangdong, China

4. Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China

Abstract

The G. lemaneiformis polysaccharide GP90 potentiates chemotherapy sensitivity by targeting the transferrin receptor and SLC7A11/Gpx4 pathway to induce ferroptosis.

Funder

Natural Science Foundation of Guangdong Province

Special Project for Research and Development in Key areas of Guangdong Province

Special Project for Marine Economy Development of Guangdong Province

Basic and Applied Basic Research Foundation of Guangdong Province

Institution of South China Sea Ecology and Environmental Engineering

Key Research and Development Project of Hainan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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