trans-Palmitoleic acid promotes adipose thermogenesis to reduce obesity via hypothalamic FFAR1 signaling

Author:

Zhan Huidong123ORCID,Wang Wanjing4,Ge Yueping123,Liang Yixiao123,Wang Jing123,Xu Yang123,Wu Shanshan123,Peng Li123,He Zhao1234

Affiliation:

1. Department of Endocrinology, Shandong Provincial Hospital & Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China

2. Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China

3. Key Laboratory of Cardiovascular Remodeling and Function Research, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

4. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China

Abstract

Dietary TG form TPA is digested or metabolized to free TPA and then act as a signaling molecule in the hypothalamus to increase adipose thermogenesis by activating the sympathetic nervous system. The effect of TPA on adipose thermogenesis relies on the hypothalamic FFAR1 signaling pathway.

Funder

National Natural Science Foundation of China

Shandong University

Publisher

Royal Society of Chemistry (RSC)

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