Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice-Reference-Cited by-同舟云学术

Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice

Published:2023 Issue:11 Volume:14 Page:5205-5216
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yan Nan¹,Wang Shuai²,Gao Haotian²,Chen Jiaqi²,Cao Jiahui³,Wei Pengsheng²,Li Xue²,Yu Ying⁴,Wang Yan⁵,Niu Yalin²,Wang Yijie²,Liu Shuyuan³⁶,Jin Ge³⁶^ORCID

Affiliation:

1. School of Medical Applied Technology, Shenyang Medical College, Shenyang, 110034, P.R. China

2. Basic Medical School, Shenyang Medical College, Shenyang, 110034, P.R. China

3. School of Pharmacy, Shenyang Medical College, Shenyang, 110034, P.R. China

4. Liaoning Medical Device Test Institute, Shenyang, 110171, P.R. China

5. Department of Occupational and Environmental Health, School of Public Health, Shenyang Medical College, Shenyang, 110034, P.R. China

6. Key Laboratory of Behavioral and Cognitive Neuroscience of Liaoning Province, Shenyang Medical College, Shenyang, 110034, P.R. China

Abstract

Aloe emodin attenuated motor and cognitive dysfunction in HD model mice. Aloe emodin decreased the level of the mutant huntingtin protein and inhibited CaMKII/Smad and TGF-β1/Smad signaling.

Funder

Department of Education of Liaoning Province

Department of Science and Technology of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00156C

Reference52 articles.

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4. Delayed ALK5 inhibition improves functional recovery in neonatal brain injury

5. SMAD Transcription Factor, Sma-9, Attunes TGF-β Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans

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