Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles

Author:

Lopez-Blanco Roi1234,Fernandez-Villamarin Marcos1234,Jatunov Sorel1234,Novoa-Carballal Ramon1234,Fernandez-Megia Eduardo1234ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica

2. Universidade de Santiago de Compostela

3. 15782 Santiago de Compostela

4. Spain

Abstract

Dendritic-polysaccharide PIC micelles represent promising delivery systems where dendritic rigidity and polysaccharide stiffness synchronize to determine the stability of the micelles, their kinetics of intracellular drug release, and cytotoxicity.

Funder

Ministerio de Ciencia, Innovación y Universidades

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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